Determination of macrophage chemotaxis to atherosclerotic plaque extract in domestic turkeys with hypertension

Autor: P D, Johnson, P H, Klesius, L M, Krista
Rok vydání: 1990
Předmět:
Zdroj: American journal of veterinary research. 51(8)
ISSN: 0002-9645
Popis: The chemotactic activity of turkey peritoneal macrophages in response to an atherosclerotic plaque extract from a hypertensive strain of turkeys was determined. Atherosclerotic plaque extract stimulated macrophage chemotaxis, whereas normal aortic extract did not stimulate macrophage chemotaxis. However, differences were not revealed by sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis of extracts of atherosclerotic plaque and normal aorta. Chemotactic activity was diminished with pronase treatment, suggesting the chemo-attractant is a protein. Seemingly, atherosclerotic plaque of turkeys contains a macrophage chemotaxin.
Databáze: OpenAIRE