Cardiac Development in the Presence of Cadmium: An

Autor:	Xian, Wu, Yichang, Chen, Anthony, Luz, Guang, Hu, Erik J, Tokar
Rok vydání:	2022
Předmět:	Organoids Human Embryonic Stem Cells Humans Cell Differentiation Myocytes Cardiac Cadmium Transcription Factors
Zdroj:	Environmental health perspectives. 130(11)
ISSN:	1552-9924
Popis:	Exposure to cadmium (Cd) is associated with cardiovascular diseases. Maternal Cd exposure is a significant risk factor for congenital heart disease. However, mechanisms of Cd on developmental cardiotoxicity are not well defined.We evaluated the effects of Cd on the different stages (mesoderm, cardiac induction, cardiac function) of cardiac development using an early embryo developmentEmbryonic stem cells (ESCs) form 3D aggregates, called embryoid bodies, that recapitulate events involved with early embryogenesis (e.g., germ layer formation). This model was used for early germ layer formation and signaling pathway identification. The 2D cardiomyocyte differentiation from theCd (In conclusion, using a human ESC-derived 2D/3D
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9e4204715641558f45d0067f32361713 https://pubmed.ncbi.nlm.nih.gov/36321828 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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