| Popis: |
A new method of compelling rats and mice to perform uninterrupted dynamic work has been devised. The animal, fixed from its tail and situated in vertical position in respect to the surface of the water with which it comes in contact only with its muzzle and forepaws, is compelled to execute uninterrupted muscular work. Total exhaustion is determined by the cessation of muscular activity, as a result of which the animal, choked by water, perishes. The method is suitable for carrying out the screening of pompounds having adaptogenic properties, for studying the mechanism of raising the endurance; it also allows registration of physiological parameters in the course of the experiment. |
