| Autor: |
O S, Brusov, V I, Dikaia, I M, Gubergrits, A N, Piatnitskiĭ, G P, Zlobina, M I, Faktor, O A, Pavlova, R R, Lideman, G P, Panteleeva |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 95(4) |
| ISSN: |
1997-7298 |
| Popis: |
The changes of main platelet serotonergic parameters (maximal velocity of 3H-serotonin uptake, Vmax; and density of (3)3H-imipramine binding sites, Bmax) were followed up in 25 endogenously depressed patients before and after electroconvulsive therapy (ECT). It was found a marked decrease in the velocity of 3H-serotonin uptake into platelets (Vmax) from patients before ECT (especially in non-responder group) and the significant increase of Vmax- and Bmax-values after the course of ECT in responders but not in resistant patients (non-responders). The increase of Vmax- and Bmax-values in responders was evidence of the rise of the functional activity serotonin system after treatment. The results evidence about the significance of serotonergic-mechanisms in the therapeutic efficacy of ECT. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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