Changes in multimodality functional imaging parameters early during chemoradiation predict treatment response in patients with locally advanced head and neck cancer

Autor:	Kee H, Wong, Rafal, Panek, Alex, Dunlop, Dualta, Mcquaid, Angela, Riddell, Liam C, Welsh, Iain, Murray, Dow-Mu, Koh, Martin O, Leach, Shreerang A, Bhide, Christopher M, Nutting, Wim J, Oyen, Kevin J, Harrington, Kate L, Newbold
Rok vydání:	2017
Předmět:	Adult Male Chemoradiotherapy Middle Aged Multimodal Imaging Diffusion Magnetic Resonance Imaging Fluorodeoxyglucose F18 Head and Neck Neoplasms Positron Emission Tomography Computed Tomography Positron-Emission Tomography Carcinoma Squamous Cell Humans Female Aged
Zdroj:	European journal of nuclear medicine and molecular imaging. 45(5)
ISSN:	1619-7089
Popis:	To assess the optimal timing and predictive value of early intra-treatment changes in multimodality functional and molecular imaging (FMI) parameters as biomarkers for clinical remission in patients receiving chemoradiation for head and neck squamous cell carcinoma (HNSCC).Thirty-five patients with stage III-IVb (AJCC 7th edition) HNSCC prospectively underwentThere were 27 responders and 8 non-responders. Responders showed a greater reduction in PET-derived tumor total lesion glycolysis (TLGEarly intra-treatment changes in FDG-PET, DW and DCE MRI-derived parameters are predictive of ultimate response to chemoradiation in HNSCC. However, the optimal timing for assessment with FDG-PET parameters (week 1) differed from MRI parameters (week 2). This highlighted the importance of scanning time points for the design of FMI risk-stratified interventional studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9dfa0730cd4c883425432f64153c10a3 https://pubmed.ncbi.nlm.nih.gov/29164301 Zobrazit plný text záznamu Full text from SpringerLink