| Autor: |
Mitchell, Nides, Elbert D, Glover, Victor I, Reus, Arden G, Christen, Barry J, Make, Clare B, Billing, Kathryn E, Williams |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
American journal of health behavior. 32(6) |
| ISSN: |
1087-3244 |
| Popis: |
To evaluate varenicline's efficacy for smoking cessation versus bupropion SR and placebo and to explore whether factors typically predictive of abstinence influence varenicline's efficacy versus placebo, as measured by the week 9-12 continuous abstinence rate (CAR9-12).Smokers in 2 randomized, placebo-controlled trials received varenicline 1 mg BID (n=696), bupropion SR 150 mg BID (n=671), or placebo (n=685) for 12 weeks. Nontreatment followup lasted 40 weeks.CAR(9-12) was greater for varenicline (44.0%) versus bupropion SR (29.7%; P0.0001) and placebo (17.7%; P0.0001). CAR(9-12) for varenicline versus placebo was not affected by age, gender, or nicotine dependence level.Varenicline was more efficacious than bupropion SR or placebo. Varenicline's efficacy versus placebo was not influenced by factors predictive of abstinence. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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