| Autor: |
V E, Ryzhenkov, A M, Chistiakova, Iu V, Frolova, V T, Lozovskiĭ, I Iu, Kameneva, L E, Vasil'eva |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Patologicheskaia fiziologiia i eksperimental'naia terapiia. (4) |
| ISSN: |
0031-2991 |
| Popis: |
Models of experimental dyslipoproteinemias have been developed by using non-inbred rats (males and females) and guinea-pigs. Administration of cholesterol (C) with fats and supplementation of 4-hydroxy-6-methyl-2-thiouracil to male rats and that of C in the mixture of fats to guinea-pigs have been demonstrated to lead to the development of atherogenic dyslipoproteinemias. Genfibrozil, cholestyramine and vasosan II, a new pectin-enriched formulation, promoted normalization of the impaired serum lipoprotein spectrum caused by exogenous C administration. Bilateral ovariectomy in female rats induced atherogenic dyslipoproteinemia. The use of the estrogen derivative methyl ether of 6-oxa-D-homo-8-isoestrone normalized lipid and lipoprotein metabolic disturbances. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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