| Autor: |
Zhijia, Li, Muzhou, Teng, Yinbo, Jiang, Litian, Zhang, Xi, Luo, Yuhui, Liao, Bin, Yang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Frontiers in immunology. 13 |
| ISSN: |
1664-3224 |
| Popis: |
Previous studies have confirmed that the bacteriumWe first assessed m6A levels in TP-infected macrophages differentiated from the human monocyte cell line THP-1. The binding and interaction between the m6A "writer" methyltransferase-like 3 (METTL3) or the m6A "reader" YT521-B homology (YTH) domain-containing protein YTHDF1 and the suppressor of cytokine signaling 3 (SOCS3), as a major regulator of the inflammatory response, were explored in differentiated TP-infected THP-1 cells as well as in secondary syphilitic lesions from patients. The mechanisms by which YTHDF1 and SOCS3 regulate the inflammatory response in macrophages were assessed.After macrophages were stimulated by TP, YTHDF1 was upregulated in the cells. YTHDF1 was also upregulated in the syphilitic lesions compared to adjacent tissue in patients. YTHDF1 recognizes and binds to the m6A methylation site of |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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