| Autor: |
V V, Iasnetsov, E P, Prosvirova, E G, Tsublova, Vik V, Iasnetsov, V G, Motin, S K, Karsanova |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine. 46(6) |
| ISSN: |
0233-528X |
| Popis: |
Experiments with mice showed that, unlike reamberin (100 mg/kg), mexidol (100 mg/kg) and cytoflavin (1 ml/kg) act as antihypoxants in pressure and hermetic chambers but not in case of acute hemic and histotoxic hypoxia. Amtisol succinate (100 mg/kg), a reference antihypoxant, excels the other tried succinate-containing drugs in all models of acute hypoxia except the hermetic chamber. In addition, the neuroprotective action of mexidol (100 mg/kg/d) and cytoflavin (100 ml/kg/d) in rats with induced ischemic stroke which was stronger than that of reamberin and amtisol succinate (100 mg/kg/d). Besides, mexidol (100 mg/kg) but not cytoflavin (1 ml/kg), reamberin or amtisol succinate (100 mg/kg) had a distinct analgesic effect in rabbits. On the neuronal level, mexidol interacts with the GABAA- benzodiazepine-receptor complex in nearly 60% cells and inhibits ion currents through the NMDA-receptor ion channels in nearly 80% neurons. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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