| Popis: |
Analyzes in the paper are chief pharmacological effects of pentoxifylline; the necessity is substantiated of its prescription in a combined therapy of systemic scleroderma (SSD). As many as 220 SSD patients on an in-patient care were examined. Apart from general clinical, biochemical, immunological methods of investigation, the condition of the microcirculation system was studied, the level of the tumor necrosis serumal factor alfa (TNF-alpha) was measured. The data secured suggest a considerable increase in the level of TNF-alpha and pronounced disturbances in microcirculation. The administration of pentoxifylline to SSD patients has been found to improve the microcirculation and reduce the production of the above factor, which fact suggests its immunomodulating properties. |
