| Autor: |
Xin, Wang, Amol J, Ghia, Zhongxiang, Zhao, Jinzhong, Yang, Dershan, Luo, Tina M, Briere, Ramiro, Pino, Jing, Li, Mary F, McAleer, David C, Weksberg, Eric L, Chang, Paul D, Brown, James N, Yang |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Journal of radiosurgery and SBRT. 4(3) |
| ISSN: |
2156-4639 |
| Popis: |
To assess the dosimetric effects of respiratory motion on the target and spinal cord in spinal stereotactic body radiation therapy (SBRT).Thirty patients with 33 lesions were enrolled on a prospective clinical protocol and simulated with both free-breathing and four-dimensional (4-D) computed tomography (CT). We studied the target motion using 4-D data (10 phases) by registering a secondary image dataset (phase 1 to 9) to a primary image dataset (phase 0) and analyzing the displacement in both translational and rotational directions. The study of dosimetric impacts from respiration includes both the effect of potential target and spinal cord motion and anatomic changes in the beam path. A clinical step-and-shoot IMRT plan generated on the free-breathing CT was copied to the 4-D datasets to evaluate the difference in the dose-volume histogram of target and normal tissues in each phase of a breathing cycle.Twenty three lesions had no motion in a breathing cycle; four lesions had anterior-posterior motion ≤ 0.2 mm; two lesions had lateral motion ≤ 0.2 mm; and eight lesions had superior-inferior motion, most ≤ 0.2 mm with the worst at 0.6 mm. The difference of maximum dose to 0.01 cmBreathing induced target and spinal cord motion is negligible compared with other setup uncertainties. Dose calculation using averaged or free-breathing CT is reliable when posterior beams are used. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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