Maintenance of IL-12-responsive CD4+ T cells during a Th2 response in Leishmania major-infected mice

Autor:	B D, Hondowicz, A Y, Park, M M, Elloso, P, Scott
Rok vydání:	2000
Předmět:	CD4-Positive T-Lymphocytes Mice Inbred BALB C Mice Inbred C3H Receptors Interleukin-12 Antibodies Monoclonal Leishmaniasis Cutaneous Antigens Protozoan Receptors Interleukin Th1 Cells Interleukin-12 Immunophenotyping Mice Th2 Cells Animals Female Lymph Nodes L-Selectin Leishmania major
Zdroj:	European journal of immunology. 30(7)
ISSN:	0014-2980
Popis:	BALB/c and anti-IL-12-treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB/c mice, C3H mice treated transiently with an anti-IL-12 monoclonal antibody switch from a Th2 to a Th1 response and resolve their lesions once treatment is terminated. We report here that the critical difference in the Th2 response between BALB/c and C3H mice is in their ability to respond to IL-12. Thus, C3H mice with a Th2 response maintain a CD4+ T cell population that expresses IL-12 receptor beta1 and beta2 mRNA and produces IFN-gamma after exposure to IL-12. These results indicate that Th2 cell populations from different genetic backgrounds differ in their stability, and that this difference can be related to differential regulation of the IL-12 receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9d4accea04f6bbff65c316cb7e025ff2 https://pubmed.ncbi.nlm.nih.gov/10940890 Zobrazit plný text záznamu Plný text