| Autor: |
Ho-Ryun, Won, Eonju, Jeon, Da Beom, Heo, Jae Won, Chang, Minho, Shong, Je Ryong, Kim, Hyemi, Ko, Yea Eun, Kang, Hyon-Seung, Yi, Ju Hee, Lee, Kyong Hye, Joung, Ji Min, Kim, Younju, Lee, Sung-Woo, Kim, Young Ju, Jeong, Yong Bae, Ji, Kyung, Tae, Bon Seok, Koo |
| Rok vydání: |
2022 |
| Zdroj: |
Annals of surgical oncology. |
| ISSN: |
1534-4681 |
| Popis: |
Active surveillance (AS) of low-risk T1a papillary thyroid carcinoma (PTC) is generally accepted as an alternative to immediate surgery. The cut-off in the size criterion for AS has recently been extended in select individuals, especially older patients. We evaluated the clinicopathological differences of T1b PTC according to age to investigate the possibility of AS in older patients.From a cohort study of 1269 patients undergoing lobectomy for PTC, 1223 PTC patients with T1 stage disease (tumor ≤ 2 cm) were enrolled. The clinicopathological characteristics between T1a and T1b patients according to age were analyzed.Among the 1223 T1 cases, 918 (75.1%) were T1a (≤ 1 cm) and 305 (34.9%) T1b (1 and ≤ 2 cm). T1b PTC was associated with male sex, minimal extrathyroidal extension, lymphovascular invasion, occult central lymph node (LN) metastasis, and a higher number of metastatic LNs than T1a. However, in patients over 55 years of age, the clinicopathological features of the patients with T1a and T1b PTC were not significantly different except for minimal extrathyroidal extension, although many clinicopathological differences were observed in patients under 55 years of age.The clinicopathological features of patients with T1b PTC over 55 years of age are similar to those with T1a PTC and less aggressive than those with T1b PTC under 55 years of age. These findings suggest that AS may be possible in patients with T1b PTC over 55 years of age without high-risk features on preoperative examinations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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