| Autor: |
N V, Strahan, E A, Murphy, N J, Fortuin, P C, Come, J O, Humphries |
| Rok vydání: |
1983 |
| Předmět: |
|
| Zdroj: |
The American journal of medicine. 74(6) |
| ISSN: |
0002-9343 |
| Popis: |
The families of 12 probands with classic mitral valve prolapse were studied for evidence of mitral valve prolapse. Seventy parents, sibs, and progeny were included in the analysis. Forty-seven percent (16 of 34) of progeny were affected compared with 30 percent (3 of 10) of parents. Thirty-eight percent (10 of 26) of sibs were affected. A three-compartmental penetrance model was devised to account for the variation in expression with age. This includes a latent stage (time before onset of signs), an affected stage, and a stage in which the subjects are withdrawn (because of treatment, regression, or death). The implications of this model are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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