A late IL-33 response after exposure to Schistosoma haematobium antigen is associated with an up-regulation of IL-13 in human eosinophils
| Autor: | Wilson, S, Jones, F M, Fofana, H K M, Landouré, A, Kimani, G, Mwatha, J K, Sacko, M, Vennervald, B J, Dunne, D W |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Adolescent Receptors Cell Surface Praziquantel Schistosomiasis haematobia Schistosomicides Young Adult schistosomiasis parasitic diseases Animals Humans human Child helminth Interleukin-13 Interleukins ST2 Interleukin-33 Interleukin-1 Receptor-Like 1 Protein Up-Regulation Eosinophils IL-13 Antigens Helminth Child Preschool IL-33 Schistosoma haematobium Brief Definitive Reports Female Interleukin-5 |
| Zdroj: | Parasite Immunology |
| ISSN: | 1365-3024 0141-9838 |
| Popis: | IL-33, a proposed alarmin, stimulates innate immune cells and Th2 cells to produce IL-13 and is rapidly upregulated upon antigen exposure in murine helminth infection. The human IL-33 response to helminth antigen was analysed in Malians infected with Schistosoma haematobium by disrupting parasite integrity via chemotherapy. Plasma IL-33 was measured pretreatment, and 24 h and 9 weeks post-treatment. At 24 h post-treatment, IL-33 levels were low. Nine week post-treatment IL-33 levels were elevated and were associated with an increase in intracellular IL-13 in eosinophils. Up-regulation of intracellular IL-13 in eosinophils was also associated with eosinophil expression of ST2L, the IL-33 receptor. IL-33 may play an important downstream role in the human response to schistosome adult worm antigen exposure. |
| Databáze: | OpenAIRE |
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