[Distribution of 5-fluorouracil between lymphocytes and blood plasma]

Autor: M A, Stashkevich, E V, Khomutov, O P, Shatova, Iu V, Dumanskiĭ, I I, Zinkovich
Rok vydání: 2013
Předmět:
Zdroj: Ukrains'kyi biokhimichnyi zhurnal (1999 ). 85(4)
Popis: In blood plasma of 8 healthy volunteers with resuspended lymphocytes incubated with 5-fluorouracil (5-FU) the drug distribution between cells and liquid was assessed by means of HPLC. Rapid accumulation of 5-FU in lymphocytes was proved (the drug concentration on the 3-rd minute is 2.5-fold higher than in plasma) as well as the absence of temporal changes of 5-FU content both in lymphocytes and blood plasma during 30 minutes of experiment.
Databáze: OpenAIRE