| Autor: |
Marta, Stojak, Lidia, Mazur, Malgorzata, Opydo-Chanek, Malgorzata, Lukawska, Irena, Oszczapowicz |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Anticancer research. 32(12) |
| ISSN: |
1791-7530 |
| Popis: |
In the search for new derivatives of anthracycline antibiotics, formamidinodaunorubicins containing in the amidine group either a morpholine moiety (DAUFmor) or a hexamethyleneimine moiety (DAUFhex) were synthesized. The biological effects of daunorubicin (DAU), DAUFmor and DAUFhex were compared.The experiments were performed on human acute lymphoblastic leukemia MOLT-4 cells and human acute myeloblastic leukemia ML-1 cells. The research was conducted using the spectrophotometric 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay and the electronic Beckman-Coulter method.Temporary changes in the leukemia cell viability, size and count were found. The antileukemic activities of the new DAU analogs were weaker than that of daunorubicin. MOLT-4 cells were more sensitive than ML-1 cells to the action of all agents. Among the formamidinodaunorubicins, DAUFmor appeared to be more active in ML-1 cells than DAUFhex, but there were not differences between the analyzed values in MOLT-4 cells.The structural modifications of daunorubicin were responsible for the different antileukemic potentials of the two formamidinodaunorubicins. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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