The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study
| Autor: | Ján, Prasko, Beata, Pasková, Richard, Záleský, Tomás, Novák, Miloslav, Kopecek, Martin, Bares, Jirí, Horácek |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder Drug Resistance Prefrontal Cortex Electric Stimulation Therapy Neuropsychological Tests Combined Modality Therapy Severity of Illness Index Transcranial Magnetic Stimulation Statistics Nonparametric Paroxetine Treatment Outcome Double-Blind Method Antidepressive Agents Second-Generation Humans Female Selective Serotonin Reuptake Inhibitors |
| Zdroj: | Neuro endocrinology letters. 27(3) |
| ISSN: | 0172-780X |
| Popis: | The goal of our study is to assess whether transcranial magnetic stimulation (rTMS) would facilitate the effect of antidepressant in OCD patients.The aim of the randomized, double-blind, sham controlled study was to compare the 2 and 4 week efficacy of the 10 sessions rTMS with sham rTMS in serotonin reuptake inhibitor resistant OCD patient. Thirty three right-handed patients were randomly assigned to either active rTMS or to sham rTMS. Active rTMS with the frequency of 1 Hz at 110% of motor threshold (MT) was administered over the left dorso-lateral prefrontal cortex. The same time schedule was used for sham administration. Thirty patients finished the study, three patients' dropped out at the beginning. Psychopathology was assessed by CGI, HAMA, Y-BOCS and BAI before the treatment, immediately after the experimental treatment, and 2 weeks after the experimental treatment by an independent reviewer.Both groups improved during the study period but the treatment effect did not differ between them in any of the instruments.Low frequency rTMS administered over the left dorso-lateral prefrontal cortex during 10 daily sessions did not differ from sham rTMS in facilitating the effect of serotonin reuptake inhibitors in OCD patients. |
| Databáze: | OpenAIRE |
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