| Autor: |
Hui-Xia, Zhou, Huan, Liu, Xue, Han, Sheng-Jie, Nie, Rong-Ping, Zhang, Jian-Yun, Yu, Shu-Hua, Li |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Fa yi xue za zhi. 37(5) |
| ISSN: |
1004-5619 |
| Popis: |
To explore the possible mechanism of Yunaconitine poisoning by studying the changes of urine metabolic profile in rats chronically poisoned by Yunaconitine via non-targeted metabolomics.A rat model of Yunaconitine poisoning was established, and a metabolomics method based on UPLC-QTOF-MS technology was used to obtain the urine metabolic profile. Principal component analysis (PCA), orthogonal projections to latent structures-discriminant analysis (OPLS-DA), variable importance in projection (VIP) value greater than 1, fold change (FC) value greater than 3 or less than 0.33 andSixteen potential biomarkers includingYunaconitine may cause neurotoxicity, hepatotoxicity and cardiotoxicity by affecting amino acid and glucose metabolism. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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