| Autor: |
A, Sakalová, Z, Herrmann, S, Gazová, I, Chabronová, L, Dedík, M, Mistrík, M, Hrubisko |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Vnitrni lekarstvi. 44(11) |
| ISSN: |
0042-773X |
| Popis: |
The problem of osteoporosis is world-wide in people above 50 years of age. As this period is also a risk period for the development of multiple myeloma or other malignant processes, comprehensive differential diagnosis of malignant and benign osteoporosis is essential. By retrospective analysis of a 12-year group of 270 patients treated by chemotherapy on account of multiple myeloma the authors selected a group of 151 patients treated in addition to chemotherapy and immunomodulating drugs (mixture of proteolytic enzymes-Wobe Mugos) for 2-3 years, also with biphosphonates. At the time ofdiagnosis osteoporosis was in 24.5% patients the only finding on bones. When biphosphonates (Bonefos, Ibandronate) and chemotherapy were administered during a three-year observation period the bone process was stable in 61.59%, osseous changes disappeared in 11.26% and progression of osteolysis was recorded in 27.15%. The objective of the work was to emphasize the importance of a correct diagnosis of osseous changes which can progress even in clinically asymptomatic myelomas. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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