The effects of green cardamom supplementation on blood pressure and endothelium function in type 2 diabetic patients
| Autor: | Ghazi Zahedi, Shohreh, Koohdani, Fariba, Qorbani, Mostafa, Siassi, Fereydoun, Keshavarz, Ali, Nasli-Esfahani, Ensieh, Aghasi, Mohadeseh, Khoshamal, Hoorieh, Sotoudeh, Gity |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Blood Pressure Iran endothelial dysfunction Double-Blind Method Study Protocol Clinical Trial Humans Endothelium Obesity Randomized Controlled Trials as Topic Elettaria diabetes blood pressure trial protocol Blood Pressure Determination Middle Aged Overweight Treatment Outcome Diabetes Mellitus Type 2 Dietary Supplements Female green cardamom Biomarkers Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Introduction: Cardamom possesses antioxidant, anti-inflammation, and blood pressure lowering properties, which might improve endothelial function in type 2 diabetic patients. However, no study has examined the effect of cardamom on diabetic patients. The present study aimed to examine the effects of 10-week green cardamom intake on blood pressure, concentrations of inflammatory and endothelial function biomarkers in type 2 diabetes mellitus patients, and its potential mechanisms. Methods and Analysis Design: Eighty overweight or obese patients with type 2 diabetes mellitus (aged 30–60 years) will be recruited into the trial and will assign to receive either cardamom (3 g/day, 6 capsules) or placebo (rusk powder, 6 capsules) for a period of 10 weeks. Systolic blood pressure and diastolic blood pressure, asymmetric dimethylarginine, and nitric oxide will be measured. Serum inflammatory markers namely interleukin 6, tumor necrosis factor-α, high-sensitivity C-reactive protein, and factors related to endothelial function including intercellular adhesion molecule-1, vascular cell adhesion molecule 1, CD62 antigen-like family member E, and cluster of differentiation 163 will be measured at baseline and at the end of the trial. Sociodemographic, International Physical Activity Questionnaire, and three 24-hour dietary recall questionnaires will be collected for each participant. Ethics and dissemination: The study has been approved by The Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.REC.1395.2700). Each participant will sign a written informed consent at the beginning of the study. At the end of the study, results will be published timely manner. Trial registration number: (http://www.irct.ir, identifier: IRCT-2016042717254N5) Date of registration: 2016-11-23 |
| Databáze: | OpenAIRE |
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