| Autor: |
D B, Duridanova, H S, Gagov, T B, Bolton |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Cellular and molecular biology (Noisy-le-Grand, France). 51(5) |
| ISSN: |
1165-158X |
| Popis: |
Distribution and enzymatic activity of haem oxygenase (HO) was investigated in the stomach of healthy guinea pigs or animals subjected to in vivo cobalt-induced oxidative stress. The physiological role of HO-1 and HO-2 isoenzymes in fundic and antral area of the stomach was assessed by studying the action of HO substrate--hemin--on ionic currents of single smooth muscle cells. The data obtained suggest that HO-1 induction might serve in the guinea-pig stomach as genetically determined defense mechanism aimed to combat toxic stress-related pathology in order to preserve the functional performance of the organ. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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