[Participation of the adenine nucleotide translocator in the regulation of pyruvate oxidation in heart mitochondria]

Autor: L I, Ivanovene, V I, Borutaĭte, V Iu, Zhilinskene, A I, Toleĭkis, A K, Prashkiavichius
Rok vydání: 1988
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 105(5)
ISSN: 0365-9615
Popis: A regulatory role of adenine nucleotide translocator (ANT) was determined by titration of mitochondrial respiration (state 3) with carboxyatractyloside. It was shown that ANT regulates pyruvate oxidation: the control strength is more pronounced after depletion of endogenous substrates or after the increase in extramitochondrial ATP/ADP. The rate of succinate oxidation is controlled mainly by succinate dehydrogenase, while ANT does not participate in its regulation.
Databáze: OpenAIRE