Subcutaneous bolus injection of deferoxamine in adult patients affected by onco-hematologic diseases and iron overload
| Autor: | C, Borgna-Pignatti, M, Franchini, G, Gandini, A, Vassanelli, M, De Gironcoli, G, Aprili |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Iron Overload Injections Subcutaneous Iron Transfusion Reaction Infusion Pumps Implantable Deferoxamine Middle Aged Hematologic Diseases Chelation Therapy Hematologic Neoplasms Myelodysplastic Syndromes Humans Patient Compliance Female Prospective Studies Infusions Intravenous Aged Chelating Agents |
| Zdroj: | Haematologica. 83(9) |
| ISSN: | 0390-6078 |
| Popis: | Chelation therapy is often necessary for patients who undergo chronic transfusion therapy for myelodysplastic syndromes. In these patients, deferoxamine, the most widely used chelating agent, has been reported to be effective in reducing the iron burden and the transfusion requirement. Unfortunately, compliance with the drug, that is usually administered by slow subcutaneous infusion via a battery operated pump, is often poor, especially in elderly patients.To verify efficacy and tolerability of deferoxamine by subcutaneous bolus injection as compared to the conventional pump-driven slow infusion, eleven patients affected by oncohematologic diseases were given 2 g of deferoxamine diluted in 10 mL of distilled water over twelve hours by continuous infusion, or by bolus injection in two divided doses.Mean urinary excretion was comparable with the two methods, being 9,183 +/- 4,349 micrograms/48 h after two daily subcutaneous bolus injections and 8,291 +/- 3,970 micrograms/48 h with the slow infusion. The bolus injection was preferred by all eleven patients, who chose to continue chelation therapy by this method.The iron excretion induced by bolus injection is not statistically different from that induced by subcutaneous infusion. The side effects are acceptable. Subcutaneous bolus injection of deferoxamine is an acceptable alternative to slow, pump-driven infusion. |
| Databáze: | OpenAIRE |
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