Expression of c-ret in the zebrafish embryo: potential roles in motoneuronal development
| Autor: | B W, Bisgrove, D W, Raible, V, Walter, J S, Eisen, D J, Grunwald |
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| Rok vydání: | 1997 |
| Předmět: |
Motor Neurons
Embryo Nonmammalian Base Sequence Molecular Sequence Data Proto-Oncogene Proteins c-ret Brain Gene Expression Regulation Developmental Receptor Protein-Tyrosine Kinases DNA Sequence Analysis DNA Zebrafish Proteins Immunohistochemistry Enteric Nervous System Branchial Region Spinal Cord Proto-Oncogene Proteins Animals Drosophila Proteins RNA Amino Acid Sequence Zebrafish |
| Zdroj: | Journal of neurobiology. 33(6) |
| ISSN: | 0022-3034 |
| Popis: | We have isolated and characterized the zebrafish ortholog of c-ret, a gene essential for renal organogenesis and enteric nervous system development in mammals. During zebrafish embryogenesis c-ret transcripts are expressed in a number of tissues including spinal motoneurons, pronephric ducts, cranial ganglia, pharyngeal arches, and the enteric nervous system. We have examined in detail the expression of c-ret during the development of identified spinal primary motoneurons. c-ret expression is regulated in a cell type-specific manner among the three primary motoneurons. c-ret is expressed at its highest levels in caudal primary (CaP) motoneurons and transcripts can be detected shortly before the expression of the CaP-specific gene, islet2. We suggest that c-ret may play a role in specifying CaP cell identity. c-ret is expressed at low levels in the other primary motoneurons and also in a subset of secondary motoneurons, suggesting that it may also play a broader role in motoneuronal survival or maintenance. |
| Databáze: | OpenAIRE |
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