| Autor: |
H R, Amouzadeh, S, Sangiah |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
Veterinary and human toxicology. 32(1) |
| ISSN: |
0145-6296 |
| Popis: |
The effects of streptozotocin-induced diabetes and insulin on the duration of xylazine-ketamine anesthesia were studied in rats. The duration of anesthesia was significantly reduced in diabetic group as compared to control group. In contrast, the duration of anesthesia in insulin-treated non-diabetic group was not significantly different from control group. The plasma glucose level in control group was increased significantly during and upon recovery from anesthesia as compared to pre-anesthetic levels. The plasma glucose level in diabetic group was not changed during anesthesia; however, it was reduced significantly upon recovery. The plasma glucose level was significantly reduced in insulin-treated group as compared to pre-anesthetic levels. The reduction in duration of anesthesia in diabetic rats is possibly due to enhanced metabolism xylazine and/or ketamine and is independent of plasma glucose level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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