| Autor: |
R D, Baynes, W R, Bezwoda, D, Dajee, R D, Lamparelli, T H, Bothwell |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 78(11) |
| ISSN: |
0256-9574 |
| Popis: |
Subcutaneous administration of alpha-interferon to normal volunteers caused hypoferraemia and hyperferritinaemia. There was, however, no concomitant rise in other components of the acute-phase response, including the serum C-reactive protein value, the granulocyte count and the plasma lactoferrin concentration. In fact, the latter two dropped significantly. The hypoferraemic response could be prolonged when a second dose was given 48 hours after the initial one. This hypoferraemic response may play a role similar to that induced by interleukin-1, which limits the proliferation of invading micro-organisms or neoplastic cells. The present findings may therefore have relevance to the clinical mechanism of action of the interferons. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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