| Autor: |
M, Loriga, P, Moro, P, Sanna, G, Paglietti, S, Zanetti |
| Rok vydání: |
1997 |
| Předmět: |
|
| Zdroj: |
Farmaco (Societa chimica italiana : 1989). 52(8-9) |
| ISSN: |
0014-827X |
| Popis: |
Thirty quinoxalines bearing a substituted anilino group on position 2, a carboethoxy or carboxy group on position 3 and a trifluoromethyl group on position 6 or 7 of the heterocycle were prepared in order to evaluate in vitro anticancer activity. Preliminary screening performed at NCI showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10(-5) and 10(-4) molar concentrations. Interesting selectivities were also recorded between 10(-8) and 10(-6) M for a few compounds. One single compound exhibited good activity against Candida albicans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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