Abnormality of hepatic triglyceride metabolism in Apc
| Autor: | Biao, Yu, Mingjun, Zhang, Jiahuan, Chen, Lingyu, Wang, Xiaohuan, Peng, Xinwei, Zhang, He, Wang, Anbei, Wang, Dazhong, Zhao, Daxin, Pang, Hongsheng, OuYang, Xiaochun, Tang |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cachexia Tumor Necrosis Factor-alpha Lipogenesis Lipolysis Fatty Acids Hyperlipidemias Hep G2 Cells Lipoproteins VLDL Lipid Metabolism Lipids Fatty Liver Mice Inbred C57BL Mice Gene Expression Regulation Liver Colonic Neoplasms Animals Humans Triglycerides Octamer Transcription Factor-1 Receptors Lipoprotein |
| Zdroj: | Life sciences. 227 |
| ISSN: | 1879-0631 |
| Popis: | Colorectal cancer syndrome has been one of the greatest concerns in the world. Although several epidemiological studies have shown that hepatic low lipoprotein lipase (LPL) mRNA expression may be associated with dyslipidemia and tumor progression, it is still not known whether the liver plays an essential role in hyperlipidemia of ApcWe measured the expression of metabolic enzymes that involved fatty acid uptake, de novo lipogenesis (DNL), β-oxidation and investigated hepatic triglyceride production in the liver of wild-type and ApcWe found that hepatic fatty acid uptake and DNL decreased, but there was no significant difference in fatty acid β-oxidation. Interestingly, the production of hepatic very low-density lipoprotein-triglyceride (VLDL-TG) decreased at 20 weeks of age, but marked steatosis was observed in the livers of the ApcAltogether, these findings highlighted a novel role of GPIHBP1 that might be responsible for hypertriglyceridemia in Apc |
| Databáze: | OpenAIRE |
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