| Autor: |
M V, Vettori, M, Goldoni, A, Caglieri, S, Palmi, L C, Ursini, A, Mutti |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Giornale italiano di medicina del lavoro ed ergonomia. 25(3) |
| ISSN: |
1592-7830 |
| Popis: |
The BMD approach has been used to compare the cell viability (MTT assay) of different rat (C6 and PC12, glial and neuronal, respectively) and human cell lines (D384 and SK-N-MC, glial and neuronal, respectively) after 24-h exposure to the following neurotoxic substances: Manganese Chloride (MnCl2), Methyl-mercury (Me-Hg) and the enantiomers of Styrene Oxide (SO). For all rat and human cell lines, the potency of the examined compounds was: MnCl2S-SOR-SOMe-Hg. A preliminary comparison with in vivo toxicity data for these substances gave rise to consistent results. Whereas a reasonable agreement between in vitro and in vivo data has been found for Mn and styrene oxide, a wide scatter of LOAEL has been reported for Me-Hg and these appear to be either much higher or lower than the BMD for the MTT assay we observed in vitro. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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