| Autor: |
A, Bernd, C, Jackel, K, Dold, F, Görmar, C, Theilig, M, Breuer, A, Ramirez-Bosca, J, Bereiter-Hahn, H, Holzmann |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 44(2) |
| ISSN: |
0004-4172 |
| Popis: |
The mode of topical action of minoxidil (U-10,858, CAS 38304-91-5) ist not entirely clear. The influence of minoxidil on the ultimate differentiation of keratinocytes was investigated. Human keratinocytes (HaCaT-cells) were incubated with minoxidil containing culture medium (10-250 micrograms/ml). Minoxidil inhibited in a concentration dependent manner cell mobility whereas the adhesion area and the cell circumference were increased. The minoxidil treated cultures had a higher desmosome density compared to parallel control cultures and they expressed the suprabasal keratins 1 and 10 (indicating progress in differentiation) earlier and to a larger extent than the controls. Keratins were revealed immunohistochemically and by two-dimensional polyacrylamide gel electrophoresis. The results suggest that minoxidil supports the differentiation of human keratinocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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