An extract of Stephania hernandifolia, an ethnomedicinal plant, inhibits herpes simplex virus 1 entry

Autor:	Joy, Mondal, Ananya, Das Mahapatra, Keshab C, Mandal, Debprasad, Chattopadhyay
Rok vydání:	2020
Předmět:	Plant Extracts Methanol Herpes Simplex Herpesvirus 1 Human Virus Internalization Models Biological Gas Chromatography-Mass Spectrometry Chlorocebus aethiops Animals Virus Activation Chloroform Medicine Traditional Vero Cells Stephania
Zdroj:	Archives of virology. 166(8)
ISSN:	1432-8798
Popis:	Stephania hernandifolia (Nimukho), an ethnomedicinal herb from rural Bengal, has been used traditionally for the management of nerve, skin, urinary, and digestive ailments. Here, we attempted to confirm the antiviral potential of aqueous, methanol, and chloroform extracts of S. hernandifolia against herpes simplex virus type 1 (HSV-1), the causative agent of orolabial herpes in humans, and decipher its underlying mechanism of action. The bioactive extract was standardized and characterized by gas chromatography-mass spectroscopy, while cytotoxicity and antiviral activity were evaluated by MTT and plaque reduction assay, respectively. Two HSV strains, HSV-1F and the clinical isolate VU-09, were inhibited by the chloroform extract (CE) with a median effective concentration (EC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9ba2350c0b3b27533f34dd3e7c1fe8d1 https://pubmed.ncbi.nlm.nih.gov/34041610 Zobrazit plný text záznamu Full text from SpringerLink