| Autor: |
Georgia, Levidou, Hariklia, Gakiopoulou, Nikolaos, Kavantzas, Angelica A, Saetta, Maria, Karlou, Petros, Pavlopoulos, Irene, Thymara, Kalliopi, Diamantopoulou, Efstratios, Patsouris, Penelope, Korkolopoulou |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
BJU international. 108(2 Pt 2) |
| ISSN: |
1464-410X |
| Popis: |
To elucidate the role of replication protein A (RPA) in both superficial (Ta-T1) and muscle-invasive (T2-T4) urothelial carcinomas (UCs), investigating its potential prognostic usefulness.Paraffin-embedded tissue from 156 patients with bladder UC was immunostained for RPA1 and RPA2.RPA1 and RPA2 labelling indexes (LIs) decreased with increasing histological grade (both P0.001) and T-category in the entire cohort (P = 0.008 and P0.001, respectively) and in muscle-invasive carcinomas (P = 0.014 and P = 0.012, respectively). RPA1 expression was positively correlated with RPA2 (Spearman's correlation coefficient ρ = 0.309, P0.001). Both RPA1 and RPA2 LIs were positively correlated with cyclin D1 expression (ρ = 0.354, P0.001 and ρ = 0.934, P0.001). In survival analysis of the entire cohort decreased RPA2 and RPA1 correlated with a lesser probability of survival (P0.001 and P = 0.018). In non-muscle-invasive tumours (Ta-T1) only lower RPA2 (P0.001) was correlated with shortened survival, whereas in muscle-invasive tumours (T2-T4) decreased RPA2 and RPA1 expression levels were associated with adverse prognosis (P = 0.035 and P = 0.042, respectively). In multivariate survival analysis of the entire cohort and in non-muscle-invasive cases RPA2 expression remained significant, even when adjustment for cyclin D1 expression was applied.RPA1 and RPA2 overexpression seems to be more important during early T-categories of bladder carcinogenesis. Showing similar kinetics with cyclin D1. RPA2 expression emerges as a valuable marker of favourable prognosis in the entire cohort and in non-muscle-invasive tumours, supplementing the information obtained by standard clinicopathological prognosticators. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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