| Autor: |
Julian, Wilke, Tatsuro, Kawamura, Hao, Xu, Alexandra, Brause, Alexandra, Friese, Malte, Metz, Dirk, Schepmann, Bernhard, Wünsch, Antonia, Artacho-Cordón, Francisco R, Nieto, Nobumoto, Watanabe, Hiroyuki, Osada, Slava, Ziegler, Herbert, Waldmann |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Cell chemical biology. 28(6) |
| ISSN: |
2451-9448 |
| Popis: |
Phenotypic screening for bioactive small molecules is typically combined with affinity-based chemical proteomics to uncover the respective molecular targets. However, such assays and the explored bioactivity are biased toward the monitored phenotype, and target identification often requires chemical derivatization of the hit compound. In contrast, unbiased cellular profiling approaches record hundreds of parameters upon compound perturbation to map bioactivity in a broader biological context and may link a profile to the molecular target or mode of action. Herein we report the discovery of the diaminopyrimidine DP68 as a Sigma 1 (σ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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