| Autor: |
Stine Gyland, Mikalsen, Lars Tore Gyland, Mikalsen, Joe Alexander, Sandvik, Eva-Katrine, Aarnes, Siri, Fenne, Kjersti, Flatmark, Heidi, Lyng, Nina Frederike Jeppesen, Edin, Erik Olai, Pettersen |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Acta oncologica (Stockholm, Sweden). 57(9) |
| ISSN: |
1651-226X |
| Popis: |
Earlier in vitro studies show that irradiation with an ultra-low dose-rate of 15 mGy/h delivered with [Clonogenicity was measured in cultured cancer cell line HT29 irradiated with 15 mGy/h combined with intermittent hypoxia. Mice with HT29 xenografts were irradiated by repeated injections of [Ultra-low dose-rate irradiation decreased clonogenicity in hypoxic colorectal cancer cells. In vivo, the tumor growth, hypoxic fraction and weight of the mice were similar between the treated and untreated group. Autoradiography showed no [Continuous low-dose-rate irradiation was well tolerated by aerobic tissue. This indicates a potential use of low dose-rate irradiation to target hypoxic tumor cells in combination with high dose-rate irradiation to eradicate the well oxygenated tumor regions. However, [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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