Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy
| Autor: | Md Abdul Hye, Khan, Munavvar Abdul, Sattar, Nor Azizan, Abdullah, Mohammed H, Abdulla, Ibrahim M, Salman, Raisa N, Kazi, K R L Anand, Swarup, Hassaan A, Rathore, Fathihah, Basri, Nurjannah M, Hussain, Aidiahmad, Dewa, Edward James, Johns |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Adrenergic Antagonists Vasodilator Agents Kidney Electric Stimulation Streptozocin Diabetes Mellitus Experimental Methoxamine Rats Disease Models Animal Norepinephrine Phenylephrine Vasoconstriction Rats Inbred SHR Receptors Adrenergic alpha-1 Hypertension Animals Vasoconstrictor Agents Diabetic Nephropathies Amlodipine |
| Zdroj: | Kidneyblood pressure research. 32(5) |
| ISSN: | 1423-0143 |
| Popis: | This study investigated the impact of hypertension combined with diabetic nephropathy on rat renal alpha(1)-adrenoceptor subtype composition.In streptozotocin-induced diabetic spontaneously hypertensive rats (SHR), diabetic nephropathy developed as reflected by increased kidney index, plasma creatinine, albumin excretion, creatinine clearance and fractional excretion of Na(+) (all p0.05). Renal vasoconstrictions caused by electrical stimulation of renal nerves and intrarenally administered noradrenaline (alpha-adrenoceptor agonist), phenylephrine (alpha(1)-adrenoceptor agonist) and methoxamine (alpha(1A)-adrenoceptor agonist) were determined in the presence and absence of intrarenally administered amlodipine (Ca(2+) channel blocker), 5-methylurapidil (alpha(1A)-adrenoceptor antagonist), chloroethylclonidine (alpha(1B)-adrenoceptor antagonist) and BMY 7378 (alpha(1D)-adrenoceptor antagonist).In diabetic nephropathy SHR, there was a significant (all p0.05) attenuation of all adrenergically induced vasoconstrictor responses in the antagonists, except chloroethylclonidine, which caused a significant (all p0.05) enhancement of the responses.The data demonstrated that there was a functional coexistence of alpha(1A)- and alpha(1D)-adrenoceptors in the renal vasculature of SHR irrespective of the presence of diabetic nephropathy. However, there was a minor contribution of pre-synaptic alpha-adrenoceptors to the adrenergically mediated vasoconstrictor responses in the diabetic nephropathy SHR. |
| Databáze: | OpenAIRE |
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