Coxiella burnetii: A Pathogenic Intracellular Acidophile

Autor:	Edward I, Shaw, Daniel E, Voth
Rok vydání:	2018
Předmět:	Type 4B Secretion System ACCM Microbe Profile Hydrogen-Ion Concentration bacterial infections and mycoses Coxiella Bacterial Proteins Coxiella burnetii Vacuoles Host-Microbe Interaction Humans Intracellular pathogenesis Q Fever Acids Bacterial Secretion Systems Genome Bacterial Phylogeny Q-fever
Zdroj:	Microbiology
ISSN:	1465-2080
Popis:	Coxiella burnetii is an obligate intracellular pathogen that causes acute and chronic Q fever. C. burnetii grows within a eukaryotic host cell in a vacuole highly similar to a phagolysosome. Found worldwide, this environmentally stable pathogen is maintained in nature via chronic infection of ruminants. Aerosol-mediated infection of humans results in infection and usurpation of alveolar macrophages through mechanisms using a bacterial Type 4B Secretion System and secreted effector proteins. Advances in axenic culture and genetic systems are changing our understanding of the pathogen’s physiology and intimate molecular manipulations of host cells during infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9b149022750acf02f1d8bce165986357 https://pubmed.ncbi.nlm.nih.gov/30422108 Zobrazit plný text záznamu