| Autor: |
Shravan Kumar, Sriraman, Christopher W, Davies, Herman, Gill, James R, Kiefer, Jianping, Yin, Annie, Ogasawara, Alejandra, Urrutia, Vincent, Javinal, Zhonghua, Lin, Dhaya, Seshasayee, Ryan, Abraham, Phil, Haas, Christopher, Koth, Jan, Marik, James T, Koerber, Simon Peter, Williams |
| Rok vydání: |
2022 |
| Zdroj: |
European journal of nuclear medicine and molecular imaging. |
| ISSN: |
1619-7089 |
| Popis: |
Cancer immunotherapies (CITs) have revolutionized the treatment of certain cancers, but many patients fail to respond or relapse from current therapies, prompting the need for new CIT agents. CD8To this end, we discovered and developed a 13-kDa single-domain antibody (VHH5v2) against human CD8 to enable high-quality, same-day imaging with a reduced radiation burden. To enable sensitive and rapid imaging, we employed a site-specific conjugation strategy to introduce anThe anti-CD8 VHH, VHH5v2, demonstrated binding to a membrane distal epitope of human CD8 with a binding affinity (KOur work reveals the potential of this anti-human CD8 VHH [ |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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