Quipazine and light have similar effects on c-fos induction in the rat suprachiasmatic nucleus

Autor:	R W, Moyer, D J, Kennaway, S A, Ferguson, Y P, Dijstelbloem
Rok vydání:	1997
Předmět:	Male Quipazine Light Animals Suprachiasmatic Nucleus Rats Wistar Proto-Oncogene Proteins c-fos Rats Serotonin Receptor Agonists
Zdroj:	Brain research. 765(2)
ISSN:	0006-8993
Popis:	The effects of the serotonin agonist, quipazine, on the induction of c-fos in the suprachiasmatic nucleus of the rat was examined at different times of the 24 h cycle. Quipazine administered at night induced Fos production in a dose dependent manner (1, 3, 10, 30 mumol/kg) in the ventrolateral portion of the suprachiasmatic nucleus at ZT18. Administration of the highest dose at other times resulted in c-fos induction at ZT15 but not at other times of the day or subjective day examined (CT6 and ZT12). When compared to the effects of light pulses (2 lux/1 min), quipazine only caused c-fos induction at times when light caused induction. Our results support a role of serotonergic pathways in the transmission or modulation of photic information from the retina to the suprachiasmatic nucleus of the rat.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9ad54b9727ea8d71650d8ccc8b7a32f0 https://pubmed.ncbi.nlm.nih.gov/9313909 Zobrazit plný text záznamu Full Text from ScienceDirect