| Autor: |
M, Soodi, N, Naghdi, H, Hajimehdipoor, S, Choopani, E, Sahraei |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Research in Pharmaceutical Sciences |
| ISSN: |
1735-5362 |
| Popis: |
Melissa officinalis L. (Labiatae) traditionally used in treating neurological disorders has also been identified as a memory-enhancing herb. The extract of M. officinalis has a cholinergic property. The role of basal forebrain cholinergic neurons, the neurons that are destroyed in Alzheimer's disease (AD), in learning and memory, is also well known. The aim of this study is to investigate the role of cholinergic system on the memory improving activity of M. officinalis extract. The leaves of M. officinalis were extracted with ethanol 80% using the maceration method. Rats received intra-peritoneal injections of M. officinalis extract in different doses (50–400 mg/kg) alone or in combination with scopolamine (1 mg/kg) before being trained in a Morris water maze (MWM) in a single-day training protocol. After training, the acetylcholinesterase enzyme (AChE) activity was measured in the hippocampus. Administration of M. officinalis extract (200 mg/kg) could significantly enhance learning and memory of naïve rats (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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