| Popis: |
Doses of 5.0, 10.0, and 20.0 mmoles/kg of t-butanol were given to C57BL/6J mice in order to study the in vivo pharmacokinetics of the alcohol in this strain. A pseudozero order decline in blood concentrations which was directly proportional to dose suggested Michaelis-Menten kinetics. PCNONLIN analysis of the data, however, yielded Vmax estimates which increased with dose and VD estimates which decreased with dose. These results are inconsistent with the Michaelis-Menten model and suggest either multiple elimination pathways or dose related effects on distribution or elimination. |
