| Autor: |
Tomohiko, Matsuta, Hiroshi, Sakagami, Shoji, Tanaka, Mamoru, Machino, Mineko, Tomomura, Akito, Tomomura, Toshikazu, Yasui, Kazuyoshi, Itoh, Tomoko, Sugiura, Madoka, Kitajima, Hiroshi, Oizumi, Takaaki, Oizumi |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
In vivo (Athens, Greece). 26(6) |
| ISSN: |
1791-7549 |
| Popis: |
Previous studies have shown antiviral, antibacterial, and anti-inflammatory activity of alkaline extract of the leaves of Sasa senanensis Rehder (SE). Here, we investigated whether SE is effective on oral lichenoid dysplasia and osteoclastogenesis.A male patient with white lacy streaks in the oral mucosa was orally administered SE three times a day for 11 months. The area of white streaks was monitored by intraoral photography. Interleukin-6 and -8 in the saliva were determined by enzyme-linked immunosorbent assay. Osteoclastogenesis of mouse macrophage-like RAW264.7 cells, induced by receptor activator of nuclear factor-κB ligand (RANKL) was monitored by tartrate-resistant acid phosphatase (TRAP)-positive multinuclear cell formation.Long-term treatment with SE progressively reduced both the area of white steaks and the levels of salivary interleukin-6 and -8. SE significantly inhibited the macrophage differentiation towards osteoclasts.The present study suggests the therapeutic potential of SE towards oral diseases. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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