Delayed Consequences of the Toxic Effect of Paclitaxel on the Testes of Prepubertal Rats and Their Correction with p-Tyrosol

Autor:	T G, Borovskaya, V A, Grigor'eva, Yu A, Shchemerova, E A, Bokhan, A V, Vychuzhanina, S I, Kamalova, V E, Goldberg
Rok vydání:	2021
Předmět:	Male Paclitaxel Testis Animals Female Phenylethyl Alcohol Rats
Zdroj:	Bulletin of experimental biology and medicine. 173(3)
ISSN:	1573-8221
Popis:	Delayed gonadotoxic effects were revealed in outbred male sexually mature rats (SD) after exposure to paclitaxel in the prepubertal period, and the possibility of their correction with p-tyrosol was shown. It was found, that administration of paclitaxel does not inhibit the ability of animals to conceive, but impairs the reserve capacity of the testicular tissue. In intact female rats crossed with male rats receiving paclitaxel, increased post-implantation fetal death was observed. Combined administration of paclitaxel and p-tyrosol alleviated the delayed effects of the cytostatic treatment on the prepubertal testis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9ac72d2944a4ebb323c693fc060641ed https://pubmed.ncbi.nlm.nih.gov/35852682 Zobrazit plný text záznamu Full text from SpringerLink