Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy

Autor:	A, Pfeufer, K J, Osterziel, H, Urata, G, Borck, H, Schuster, T, Wienker, R, Dietz, F C, Luft
Rok vydání:	1996
Předmět:	Adult Male Base Sequence Genotype Myocardium Molecular Sequence Data Serine Endopeptidases Cardiomyopathy Hypertrophic Middle Aged Peptidyl-Dipeptidase A Polymerase Chain Reaction Chymases Humans Female Alleles Polymorphism Restriction Fragment Length Aged
Zdroj:	The American journal of cardiology. 78(3)
ISSN:	0002-9149
Popis:	We examined the insertion/deletion polymorphism in the angiotensin-converting enzyme gene and identified polymorphisms in the heart chymase gene to test the hypothesis that these angiotensin II-producing enzymes are associated with a monogenic cardiac disease (50 patients and 50 control subjects) as a model of cardiac hypertrophy. We found that the angiotensin-converting enzyme DD genotype was present more often in patients than in control subjects and identified a possible interaction with 1 of the chymase polymorphisms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9ac72c6f1cd12c34c97badf9fbd8e4b0 https://pubmed.ncbi.nlm.nih.gov/8759823 Zobrazit plný text záznamu Full Text from ScienceDirect