A classification of drug substances according to their mechanism of action

Autor: P, Imming, T, Buss, L A, Dailey, A, Meyer, H, Morck, M, Ramadan, T, Rogosch
Rok vydání: 2004
Předmět:
Zdroj: Die Pharmazie. 59(8)
ISSN: 0031-7144
Popis: Different classification systems for therapeutic agents exist. The most commonly used one is the ATC Code (ATC: Anatomy, Therapeutic properties, Chemical, pharmacological properties). Here, an alternative classification system (TCAT: Target-Chemistry-Anatomy-Therapy) is proposed which refers to the molecular mechanism of action or rather, target. The main subgroups of targets are: enzymes; substrates, metabolies, proteins; receptors; ion channels; transporter molecules and systems; nucleic acids, ribosomes; physicochemical mechanisms; antigen-antibody reactions; unknown targets. This target-oriented approach may be particularly useful in teaching advanced medicinal chemistry.
Databáze: OpenAIRE