| Autor: |
Miho, Ichiba, Sadako, Yamada, Kyoko, Ishii, Kazue, Gonda, Rie, Murai, Takashi, Shimomura, Toshiya, Saeki, Takamasa, Kanbe, Yoshitada, Tanabe, Yoko, Yoshida, Hiroyuki, Tsuchiya, Yoshiko, Hoshikawa, Akihiro, Kurimasa, Yukihiro, Kishimoto, Hironaka, Kawasaki, Goshi, Shiota |
| Rok vydání: |
2007 |
| Předmět: |
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| Zdroj: |
Hepato-gastroenterology. 54(78) |
| ISSN: |
0172-6390 |
| Popis: |
Although the importance of reactive oxygen species (ROS) in the pathogenesis of various diseases is stressed, clinical significance of the markers reflecting DNA oxidation such as 8-hydroxy-2'-deoxyguanosine (8-OHdG) remains to be clarified.To examine clinical usefulness of 8-OHdG in healthy individuals in comparison with liver disease patients, urinary excretion of 8-OHdG was measured in 336 healthy individuals and 110 patients with liver disease.In healthy persons, the 8-OHdG excretion was increased in an age-dependent manner. It was positively correlated with cigarettes smoked a day and negatively correlated with body mass index (BMI) (P0.05, each). Age, smoking and BMI were independent predictors of urinary 8-OHdG excretion (P0.01, P0.01 and P0.05, respectively). In liver disease, the excretion of 8-OHdG was not changed, as compared with healthy individuals. However, the liver disease patients under the age of 40 had higher values of 8-OHdG than healthy persons. In addition, the urinary excretion of 8-OHdG was higher in patients with hepatitis C virus (HCV) infection than those with hepatitis B virus (HBV) infection.The results of the present study suggest that measurement of urinary 8-OHdG excretion is useful in assessing DNA oxidation caused by aging, smoking, body composition and liver disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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