STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D

Autor: Etienne, Masle-Farquhar, Katherine J L, Jackson, Timothy J, Peters, Ghamdan, Al-Eryani, Mandeep, Singh, Kathryn J, Payne, Geetha, Rao, Danielle T, Avery, Gabrielle, Apps, Jennifer, Kingham, Christopher J, Jara, Ksenia, Skvortsova, Alexander, Swarbrick, Cindy S, Ma, Daniel, Suan, Gulbu, Uzel, Ignatius, Chua, Jennifer W, Leiding, Kaarina, Heiskanen, Kahn, Preece, Leena, Kainulainen, Michael, O'Sullivan, Megan A, Cooper, Mikko R J, Seppänen, Satu, Mustjoki, Shannon, Brothers, Tiphanie P, Vogel, Robert, Brink, Stuart G, Tangye, Joanne H, Reed, Christopher C, Goodnow
Rok vydání: 2022
Předmět:
Zdroj: Immunity. 55(12)
ISSN: 1097-4180
Popis: The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8
Databáze: OpenAIRE