Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice
| Autor: | F C, Pimenta, E N, Miyaji, A P M, Arêas, M L S, Oliveira, A L S S, de Andrade, P L, Ho, S K, Hollingshead, L C C, Leite |
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| Rok vydání: | 2006 |
| Předmět: |
Cholera Toxin
Mouth Recombinant Fusion Proteins Gram-Positive Bacteria Antibodies Bacterial Pneumococcal Infections Immunoglobulin A Mice Inbred C57BL Pneumococcal Vaccines Mice Streptococcus pneumoniae Bacterial Proteins Immunoglobulin G Nasopharynx Microbial Immunity and Vaccines Animals Female Immunization Administration Intranasal |
| Zdroj: | Infection and immunity. 74(8) |
| ISSN: | 0019-9567 |
| Popis: | One of the candidate proteins for a mucosal vaccine antigen against Streptococcus pneumoniae is PsaA (pneumococcal surface antigen A). Vaccines targeting mucosal immunity may raise concerns as to possible alterations in the normal microbiota, especially in the case of PsaA, which was shown to have homologs with elevated sequence identity in other viridans group streptococci. In this work, we demonstrate that intranasal immunization with a cholera toxin B subunit-PsaA fusion protein is able to protect mice against colonization with S. pneumoniae but does not significantly alter the natural oral or nasopharyngeal microbiota of mice. |
| Databáze: | OpenAIRE |
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