| Autor: |
Margaret A, Flynn, Amolak, Singh, James, Slaughter, Paul, King, Gary, Krause, Victor, Herbert, Wally, Thomas |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Missouri medicine. 100(2) |
| ISSN: |
0026-6620 |
| Popis: |
To find the effect of aging, nutrition, and gender on Homocysteine-Cobalamin-Folate (HCF) Triad and to determine if B-12 supplementation decreases high levels of homocysteine.In 192 subjects, blood indices were determined to study the relationship of HCF triad to age and gender, 28 had low holotranscobalmin (TC II), and five had low serum cobalamin. Thirty-nine of the subjects who had hyperhomocysteinemia were daily given 100 mcg B-12 for three months.Thirty-six subjects with hyperhomocysteinemia exhibited different responses based on baseline serum B-12 levels. Those with serum B-12350 pg/ml decreased homocysteine and increased red blood cell (RBC) folate. The serum folate was not significantly changed. Those with B-12350 pg/ml exhibited increase in RBC folate only.B-12 supplementation is effective in alleviating hyperhomocysteinemia. Compared to men, aging women had lower homocysteine. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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