Major components of endogenous neurotransmission underlying the discharge activity of hypoglossal motoneurons in vivo

Autor:	Edward J, Zuperku, Ivo F, Brandes, Astrid G, Stucke, Antonio, Sanchez, Francis A, Hopp, Eckehard A, Stuth
Rok vydání:	2007
Předmět:	Decerebrate State Motor Neurons Hypoglossal Nerve Models Neurological Bicuculline Synaptic Transmission Dogs 2-Amino-5-phosphonovalerate Tongue Quinoxalines Models Animal Animals Ketanserin Excitatory Amino Acid Antagonists
Zdroj:	Advances in experimental medicine and biology. 605
ISSN:	0065-2598
Popis:	Multibarrel micropipettes were used to simultaneously record unit activity and apply antagonists on individual inspiratory hypoglossal motoneurons (IHMNs) to determine the endogenous activation levels of NMDA, non-NMDA, GABA(A) and serotonin receptors responsible for the IHMN spontaneous discharge patterns in decerebrate dogs. IHMN activity is highly dependent on glutamatergic phasic and tonic drives, which are differentially mediated by the receptor subtypes. Endogenous serotonin significantly amplifies IHMN activity, while GABAergic gain modulation acts to attenuate activity. Thus, alterations in the neurotransmission of any of these systems could markedly alter neuronal output to target muscles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::9a1dd7fca23333dbbc9ce110a0ed2b86 https://pubmed.ncbi.nlm.nih.gov/18085286 Zobrazit plný text záznamu